Senior Director Pharmacology

Are you an experienced oncology drug development leader with a track record of advancing therapies from discovery through regulatory approval?

We're partnering with an innovative biotechnology organization seeking a Senior Director, Oncology Pharmacology to provide scientific leadership across a diverse oncology portfolio. This individual will play a critical role in shaping nonclinical development strategy, driving pharmacology plans, and supporting programs from discovery through IND-enabling development and beyond.

Key Responsibilities

• Lead nonclinical pharmacology strategy across multiple oncology programs.
• Design and oversee studies evaluating efficacy, pharmacodynamics, mechanism of action, and biomarker strategies.
• Drive translational approaches that support candidate selection, indication expansion, and clinical development decisions.
• Collaborate closely with Toxicology, DMPK, Clinical Pharmacology, Biomarkers, Regulatory Affairs, and Clinical Development teams.
• Manage external CRO and academic partnerships.
• Contribute to regulatory submissions, including INDs, NDAs, and BLAs.
• Mentor and develop scientific talent while serving as a key leader within a highly matrixed R&D environment.

Background We're Looking For

• PhD in Pharmacology, Immunology, Biology, Biochemistry, Cancer Biology, or a related scientific discipline.
• 10+ years of industry experience in nonclinical oncology pharmacology.
• Demonstrated success advancing oncology assets from discovery through IND-enabling development.
• Experience supporting at least one approved therapeutic product and/or major regulatory submission.
• Deep understanding of oncology drug development, including solid tumors, hematologic malignancies, and/or immuno-oncology.
• Experience across multiple therapeutic modalities, including biologics and other advanced treatment platforms.
• Proven scientific leadership in cross-functional drug development teams.
• Prior people leadership experience.

Preferred Experience

• Oncology efficacy model development and execution.
• Immuno-oncology research.
• Biomarker identification and translational strategy.
• Mechanism-of-action studies.
• CRO management and outsourced pharmacology programs.
• Experience with biologics, ADCs, bispecifics, cell therapies, or other emerging oncology modalities.

Important Note

This role is focused on nonclinical/preclinical oncology pharmacology leadership. Candidates whose experience is primarily in Clinical Pharmacology, Pharmacometrics, Population PK, PK/PD Modeling, or Quantitative Clinical Pharmacology without significant ownership of oncology pharmacology programs are unlikely to be a strong fit.

Why Apply?

• Fully remote within the United States.
• Opportunity to influence high-impact oncology programs.
• Visible leadership role with broad cross-functional exposure.
• Work across multiple therapeutic modalities and cutting-edge oncology science.

Interested in learning more? Apply directly or reach out for a confidential discussion.